Contractility is the future
Miniaturize assays.
Maximize impact.
Live Cell Technologies Canada
Mechanobiology
Physics matters.
Biological cells are not static, but exert a broad range of forces that are key in healthy physiology. In diverse diseases from asthma to cardiovascular disease and cancer metastasis, this force landscape is profoundly altered. By measuring these forces, we can potentially identify and address these pathologies.
While cell contractility and cell biophysics are an emerging target of diagnostics and therapeutics in human disease, there are no clinical or industrial methods for characterizing the forces exerted by the cell. We're leading a paradigm shift toward mechanomedicine today, which will define the landscape of drug development and safety testing of tomorrow.
Products
You need direct measurements. We have the solution.
Live Cell Technologies Canada fills the growing clinical and industrial need for cell force assays by translating a biophysics lab technology, Traction Force Microscopy (TFM), to a high-throughput methodology, Contractile Force Screening (CFS). We provide end-to-end solutions to directly measure cellular contractile forces for your cell biology, health, and pharmaceutical research needs. Don’t see what you need? Not sure what would work? Let us know! We will work with you to customize solutions for your research needs.
Applications
Have a massive pool of drug prospects? Screening compounds for the next Fountain of Youth? Investigating a mechanical disease?
Whether identifying cardiac inotropes, anti-fibrotic agents, or bronchodilators, contractility force screening (CFS) is focused on the key physiological endpoint – contractile force, leading to more economical, faster, and relevant pharmaceutical development. The possibilities don’t end here; we will work with you to implement CFS in your workflow!
Innovation
Our patented CFS technology is backed up by decades of innovation from pioneers in the field of mechanobiology.
Services
Beyond the product
Customized Assays
We tailor our platform to suit your needs: 1-, 6-, 12-, 24-, 48-, 96-well plates for soft substrate studies and contractile force screening.
Analysis Software
Translate rich contractility data into meaningful insights.
1-on-1 Support
We're here to help you get the most out of your experiments, from the design stage through data analysis.
Our Clients
Our clients' work spans drug discovery, validation, and toxicity screening
Amgen
Anabios
AstraZeneca
Pfizer
An Interdisciplinary Founding Team
Our collective expertise spans the fields of physics, materials science, and physiology.
Ramaswamy Krishnan, Ph.D.
Founder
Contractile Force Screening
Mechano-pharmacology
Cell and Tissue Mechanics
Assistant Professor of Emergency Medicine at Harvard Medical School
Jeffrey Fredberg, Ph.D.
Founder
Traction Force Microscopy
Lung (Patho)physiology
Physics of Oncology
Professor of Bioengineering and Physiology, Harvard T.H. Chan School of Public Health
