Applications

Our technology can applied to virtually any physiological screen or disease with a mechanical component.

The value of Contractile Force Screening is clear: identifying therapeutic leads while eliminating false positives early in the discovery process, and identifying cardiac muscle dysfunction that may cause drug recall, leads to more economical, faster, and safer pharmaceutical development. The applications of our technology do not end there, however. From developing better cosmetic products to understanding diverse diseases, and from investigating single cell mechanics to monolayers and collective cell migration, we want to help you unlock the power behind cell forces, and look forward to working with you to make your application possible.

The science behind CFS is clear, and you can see for yourself in the numerous publications that have used our platform.

Publications

High-throughput screening for modulators of cellular contractile force.

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Latrophilin receptors: novel bronchodilator targets in asthma.

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Traction force screening enabled by compliant PDMS elastomers.

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Retinoic Acid Signaling is Essential for Airway Smooth Muscle Homeostasis.

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Multiplexed, high-throughput measurements of cell contraction and endothelial barrier function.

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High Throughput Traction Force Microscopy Using PDMS Reveals Dose-Dependent Effects of Transforming Growth Factor-β on the Epithelial-to-Mesenchymal Transition.

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Aspergillus fumigatus secreted alkaline protease 1 (Alp1) mediates airways hyper-responsiveness in severe asthma.

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Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins.

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Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.

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