The value of Contractile Force Screening is clear: identifying therapeutic leads while eliminating false positives early in the discovery process, and identifying cardiac muscle dysfunction that may cause drug recall, leads to more economical, faster, and safer pharmaceutical development. The applications of our technology do not end there, however. From developing better cosmetic products to understanding diverse diseases, and from investigating single cell mechanics to monolayers and collective cell migration, we want to help you unlock the power behind cell forces, and look forward to working with you to make your application possible.
The science behind CFS is clear, and you can see for yourself in the numerous publications that have used our platform.
High-throughput screening for modulators of cellular contractile force.DOI
Latrophilin receptors: novel bronchodilator targets in asthma.DOI
Traction force screening enabled by compliant PDMS elastomers.DOI
Retinoic Acid Signaling is Essential for Airway Smooth Muscle Homeostasis.DOI
Multiplexed, high-throughput measurements of cell contraction and endothelial barrier function.DOI
High Throughput Traction Force Microscopy Using PDMS Reveals Dose-Dependent Effects of Transforming Growth Factor-β on the Epithelial-to-Mesenchymal Transition.DOI
Aspergillus fumigatus secreted alkaline protease 1 (Alp1) mediates airways hyper-responsiveness in severe asthma.DOI
Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins.DOI
Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.DOI